Possible Interaction: Allopurinol and Glutathione

“Testing the hypothesis that xanthine oxidase contributes to the production of free radicals during exercise, we found not only … exercise caused an increase in blood xanthine oxidase activity in rats but also that inhibiting xanthine oxidase with allopurinol prevented exercise‐… oxidation of glutathione in both rats and in humans.”

“ Allopurinol in combination with either lactobionate or glutathione was markedly inhibitory (i.e., median ratio 1.8 and 1.9, respectively).”

“Treatment with allopurinol to ISO induced rats prevented the elevated activities of AST, ALT, and ALP enzymes, and the levels of lipid peroxidation products and increased reduced glutathione concentration.”

“Pretreatment with allopurinol (50 mg/kg) significantly protected against ACN-induced rise in XO activity, depletion of GSH , and elevated production of (O(2)(.-)).”

“ Allopurinol (20 mg/kg body weight) had slight effects on GSH and GSSG.”

“Pretreatment of the animals with allopurinol also diminished the formation of glutathione disulphide and thiobarbituric acid-reactive substances.”

“Pretreatment with allopurinol or administration of superoxide dismutase prevented the influx of neutrophils and retarded the drop in reduced glutathione levels.”

“The binding reaction was not inhibited by superoxide dismutase or allopurinol , but was strongly inhibited by ascorbic acid and glutathione.”