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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Allopurinol and Calcium Supplement

Research Papers that Mention the Interaction

Citrate supplements may increase the urine citrate level and increase pH. Allopurinol has shown significant efficacy for preventing formation of calcium stones in hyperuricosuric patients.
Expert opinion on pharmacotherapy  •  2015  |  View Paper
Allopurinol , an inhibitor of xanthine oxidase, increases myofilament calcium responsiveness and blunts calcium cycling in isolated cardiac muscle.
Circulation research  •  1999  |  View Paper
During the reperfusion phase, allopurinol pretreatment significantly prevented the decrease in left ventricular pressure, sodium and calcium accumulation and decreases in sarcolemmal Na+,K+-stimulated and sarcoplasmic reticulum K+,Ca2+-stimulated ATPase activities as compared with untreated animals (P less than 0.05).
Biochemical pharmacology  •  1987  |  View Paper
When allopurinol was omitted during calcium repletion , tissue protection was less apparent.
Research in experimental medicine. Zeitschrift fur die gesamte experimentelle Medizin einschliesslich experimenteller Chirurgie  •  1987  |  View Paper
Calcium stone formation can be prevented by the use of different drugs with different mechanisms of action (thiazide diuretics, allopurinol , and potassium citrate), but there is no ideal drug that is both risk free and well tolerated.
F1000Research  •  2016  |  View Paper