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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Allopurinol and Ascorbate

supplement:

Ascorbate

Research Papers that Mention the Interaction

Also, the rate constant (k) for the copper-catalyzed aerobic oxidation of ascorbate was markedly decreased in the presence of allopurinol (from 0.068 min-1 to 0.014 min-1).
Free radical research communications  •  1993  |  View Paper
Allopurinol (50 mg kg-1 by gavage), an inhibitor of xanthine oxidase which catalyses oxidation of xanthine to UA, decreased basal UA and AA concentrations and the morphine-induced increase in DA metabolites and AA oxidation.
Pharmacological research  •  1997  |  View Paper
Coadministration of allopurinol and dynorphin further spiked the ascorbate levels (0.28 +/- 0.05, p < 0.01).
Free radical biology & medicine  •  1995  |  View Paper
Allopurinol also inhibits the activation of the enzyme in vitro by ascorbate , ethanol plus NAD(+), NADH, hypoxanthine or xanthine.
The Biochemical journal  •  1973  |  View Paper