supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 4 years ago
drug:
Allopurinol
supplement:
Ascorbate
Research Papers that Mention the Interaction
“Also, the rate constant (k) for the copper-catalyzed aerobic oxidation of ascorbate was markedly decreased in the presence of allopurinol (from 0.068 min-1 to 0.014 min-1).”
Interaction between allopurinol and copper: possible role in myocardial protection.“ Allopurinol (50 mg kg-1 by gavage), an inhibitor of xanthine oxidase which catalyses oxidation of xanthine to UA, decreased basal UA and AA concentrations and the morphine-induced increase in DA metabolites and AA oxidation.”
Effects of allopurinol on striatal dopamine, ascorbate and uric acid during an acute morphine challenge: ex vivo and in vivo studies.“Coadministration of allopurinol and dynorphin further spiked the ascorbate levels (0.28 +/- 0.05, p < 0.01).”
“ Allopurinol also inhibits the activation of the enzyme in vitro by ascorbate , ethanol plus NAD(+), NADH, hypoxanthine or xanthine.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback