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Discover Supplement-Drug Interactions

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Last Updated: 7 months ago

Possible Interaction: Allo-L-Isoleucine and Isoleucine

supplement:

Isoleucine

Research Papers that Mention the Interaction

Evidence presented here suggests that racemization of the 3-carbon of L-isoleucine occurs during transamination, that L-alloisoleucine is an inherently unavoidable by-product of L-isoleucine transamination (and vice versa), and that a KMVA enol is not obligate in this racemization.
The Journal of biological chemistry  •  1992  |  View Paper
When a healthy subject was loaded with L-isoleucine , plasma levels of L-isoleucine and 3-methyl-2-oxopentanoate (KMV), as well as L-alloisoleucine , increased.
Journal of inherited metabolic disease  •  1990  |  View Paper
ALLO 0.025 mM increased ILE release by +55% but had an inconsistent effect on ILE decarboxylation and did not alter protein synthesis or degradation (estimated by phenylalanine incorporation and tyrosine release, respectively).
JPEN. Journal of parenteral and enteral nutrition  •  1986  |  View Paper
It is stated in both reports that Lisoleucine racemizes to D-alloisoleucine.
Science  •  1971  |  View Paper
Alloisoleucine , prepared from a mixture of racemic isoleucine-alloisoleucine diastereoisomers, can be heavily contaminated with isoleucine if the recrystallization of acetyl-dl-alloisoleucine is controlled by melting point only.
The Biochemical journal  •  1970  |  View Paper
Isoleucine also showed some loss through racemization to alloisoleucine.
The British journal of nutrition  •  1970  |  View Paper
Lowering the initial pH, decreasing the amounts of leucine and valine, and adapting the organism to d-alloisoleucine medium accelerated the use of isoleucine isomers.
Applied microbiology  •  1965  |  View Paper