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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
supplement:
Allo-L-Isoleucine
supplement:
Isoleucine
Research Papers that Mention the Interaction
“Evidence presented here suggests that racemization of the 3-carbon of L-isoleucine occurs during transamination, that L-alloisoleucine is an inherently unavoidable by-product of L-isoleucine transamination (and vice versa), and that a KMVA enol is not obligate in this racemization.”
On the mechanisms of the formation of L-alloisoleucine and the 2-hydroxy-3-methylvaleric acid stereoisomers from L-isoleucine in maple syrup urine disease patients and in normal humans.“When a healthy subject was loaded with L-isoleucine , plasma levels of L-isoleucine and 3-methyl-2-oxopentanoate (KMV), as well as L-alloisoleucine , increased.”
“ ALLO 0.025 mM increased ILE release by +55% but had an inconsistent effect on ILE decarboxylation and did not alter protein synthesis or degradation (estimated by phenylalanine incorporation and tyrosine release, respectively).”
Branched-chain amino acid interactions in skeletal muscle: isoleucine and L-alloisoleucine.“It is stated in both reports that Lisoleucine racemizes to D-alloisoleucine.”
Racemization and epimerization.“ Alloisoleucine , prepared from a mixture of racemic isoleucine-alloisoleucine diastereoisomers, can be heavily contaminated with isoleucine if the recrystallization of acetyl-dl-alloisoleucine is controlled by melting point only.”
“ Isoleucine also showed some loss through racemization to alloisoleucine.”
“Lowering the initial pH, decreasing the amounts of leucine and valine, and adapting the organism to d-alloisoleucine medium accelerated the use of isoleucine isomers.”
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