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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alkaline Phosphatase
supplement:
Zinc Cation
Research Papers that Mention the Interaction
“ Zn2+ , as one possible candidate, antagonized the Ni2+ inhibition of BMP-2-induced ALP in both MC3T3-E1 and human bone marrow stromal cells.”
Uptake of nickel from 316L stainless steel into contacting osteoblastic cells and metal ion interference with BMP-2-induced alkaline phosphatase.“Of the metal ions tested (Na+, Mg2+, Zn2+, and Ca2+) only Zn2+ (at 5 mM concentration) inhibited significantly the alkaline phosphatase activity of purified matrix vesicles.”
Biochemical characterization of matrix vesicles from bone and cartilage.“ Alkaline phosphatase was effectively inhibited by EDTA, Zn2+ , histidine and urea therefore resembling the inhibition characteristics of alkaline phosphatase in the placenta and kidney, but not that in the liver and intestine, which differed markedly.”
“The mutationally altered alkaline phosphatase could be activated by incubation at pH values between 5 and 6 in the presence of Zn(II ) at 37°.”
A mutationally altered alkaline phosphatase from Escherichia coli. I. Formation of an active enzyme in vitro and phenotypic suppression in vivo.
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