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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Vitamin K

Research Papers that Mention the Interaction

Either dose of MK-4 supplementation increased the alkaline phosphatase ( ALP ), decreased the undercarboxylated osteocalcin (ucOC) and tartrate-resistant acid phosphatase (TRACP, p < 0.05) levels, and presented higher BMD, percent bone volume (BV/TV), trabecular thickness (Tb.
Nutrients  •  2021  |  View Paper
In vitro studies results suggested that combined treatment with PTH and vitamin K2 increased expression of ALP , BMP2 and RUNX2 in BMSCs.
Chemico-biological interactions  •  2019  |  View Paper
The combination of vitamin K and AP , bAP and PYD resulted in increased AUC scores (>0.9).
Biomarkers : biochemical indicators of exposure, response, and susceptibility to chemicals  •  2004  |  View Paper
Vitamin K2 increased alkaline phosphatase activity in both kinds of cells.
Biochemical and biophysical research communications  •  1992  |  View Paper
Furthermore, MK-4 enhanced alkaline phosphatase ( ALP ) activity in HAVICs, and 7 days of MK-4 treatment markedly upregulated the gene expression of the calcification marker bone morphogenetic protein 2 (BMP2).
The Journal of Pharmacology and Experimental Therapeutics  •  2019  |  View Paper
Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase , insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels.
Critical reviews in food science and nutrition  •  2017  |  View Paper
Serum levels of alkaline phosphatase (ALP) increased gradually and became significant at 48 weeks after menatetrenone treatment, while urinary excretion of deoxypyridinoline (DPD) decreased transiently but significantly at 4 weeks.
Endocrine journal  •  2002  |  View Paper
The results revealed that VK2 (1 µM) significantly increased ALP activity and the conversion of microtubule associated protein 1 light chain 3-α (LC3)II to LC3I in MC3T3-E1 osteoblasts (P<0.05) at every time point.
Molecular medicine reports  •  2019  |  View Paper
In addition, VK2 upregulated the expression levels of osteogenic marker proteins, such as Runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin, which were significantly inhibited by dexamethasone.
International journal of molecular medicine  •  2017  |  View Paper
100μg/g vitamin K2 treatment decreased calcium depositions, ALP activity and apoptosis significantly, but increased Gas6, Axl, p-Akt and Bcl-2 expression.
European journal of pharmacology  •  2016  |  View Paper
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