Possible Interaction: Alkaline Phosphatase and Vitamin K

“Either dose of MK-4 supplementation increased the alkaline phosphatase ( ALP ), decreased the undercarboxylated osteocalcin (ucOC) and tartrate-resistant acid phosphatase (TRACP, p < 0.05) levels, and presented higher BMD, percent bone volume (BV/TV), trabecular thickness (Tb.”

“In vitro studies results suggested that combined treatment with PTH and vitamin K2 increased expression of ALP , BMP2 and RUNX2 in BMSCs.”

“The combination of vitamin K and AP , bAP and PYD resulted in increased AUC scores (>0.9).”

“ Vitamin K2 increased alkaline phosphatase activity in both kinds of cells.”

“Furthermore, MK-4 enhanced alkaline phosphatase ( ALP ) activity in HAVICs, and 7 days of MK-4 treatment markedly upregulated the gene expression of the calcification marker bone morphogenetic protein 2 (BMP2).”

“ Vitamin K2 has shown to stimulate bone formation by promoting osteoblast differentiation and carboxylation of osteocalcin, and increasing alkaline phosphatase , insulin-like growth factor-1, growth differentiation factor-15, and stanniocalcin 2 levels.”

“Serum levels of alkaline phosphatase (ALP) increased gradually and became significant at 48 weeks after menatetrenone treatment, while urinary excretion of deoxypyridinoline (DPD) decreased transiently but significantly at 4 weeks.”

“The results revealed that VK2 (1 µM) significantly increased ALP activity and the conversion of microtubule associated protein 1 light chain 3-α (LC3)II to LC3I in MC3T3-E1 osteoblasts (P<0.05) at every time point.”

“In addition, VK2 upregulated the expression levels of osteogenic marker proteins, such as Runt-related transcription factor 2 (Runx2), alkaline phosphatase (ALP) and osteocalcin, which were significantly inhibited by dexamethasone.”

“100μg/g vitamin K2 treatment decreased calcium depositions, ALP activity and apoptosis significantly, but increased Gas6, Axl, p-Akt and Bcl-2 expression.”