Possible Interaction: Alkaline Phosphatase and Vitamin D

“For regular monitoring, only ALP assay is recommended, provided one abstains from repeat injection of vitamin D based on high ALP levels.”

“Our in vitro study found that VitD could promote the expression of alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), bone morphogenetic protein 2 (BMP2), bone gamma-carboxyglutamate protein (BGLAP), and VDR in the early osteogenic differentiation of periodontal ligament stem cells (PDLSCs).”

“Alkaline phosphatase ALP ) activity was increased by 25(OH)D2/D3 and 1,25(OH)2D2/D3 in hBMSC and 2T3 cells, and the increase was greater with the D3 metabolites at high concentrations.”

“ Vitamin D stimulates not only active transport in the intestine, but also the activity of alkaline phosphatase and (Ca2+ t Mg2+)-ATPase [9,10].”

“Furthermore, co-treatment with leptin and vitamin D3 metabolites promoted ALP activity compared with either alone.”

“Further, it was found that the use of nHA and vitamin D3 resulted in increased expression of BGLAP and COLL I and reduced expression of ALP and RUNX2 in hADSCs for 21 days.”

“No significant postoperative change in vitamin D , calcium, or phosphate was observed, but alkaline phosphatase increased significantly (P < 0.001).”

“The meta-analysis suggested a significant reduction in alkaline phosphatase (−13.79 U/L; 95% CI, −22.13 to −5.45; I2 = 72%) following vitamin D supplementation.”

“Our findings revealed after 1-year treatment of active vitamin D3 , PTH and ALP significantly decreased.”

“The osteogenic markers, alkaline phosphatase , secreted phosphoprotein 1 (osteopontin), and bone gamma-carboxyglutamate protein (osteocalcin) are increased by 25(OH)D3 and 1α,25-(OH)2D3 in a dose-dependent manner.”