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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Vitamin D

Research Papers that Mention the Interaction

For regular monitoring, only ALP assay is recommended, provided one abstains from repeat injection of vitamin D based on high ALP levels.
Journal of clinical research in pediatric endocrinology  •  2017  |  View Paper
Our in vitro study found that VitD could promote the expression of alkaline phosphatase (ALP), runt-related transcription factor 2 (Runx2), bone morphogenetic protein 2 (BMP2), bone gamma-carboxyglutamate protein (BGLAP), and VDR in the early osteogenic differentiation of periodontal ligament stem cells (PDLSCs).
The Journal of Steroid Biochemistry and Molecular Biology  •  2021  |  View Paper
Alkaline phosphatase ALP ) activity was increased by 25(OH)D2/D3 and 1,25(OH)2D2/D3 in hBMSC and 2T3 cells, and the increase was greater with the D3 metabolites at high concentrations.
PloS one  •  2016  |  View Paper
Vitamin D stimulates not only active transport in the intestine, but also the activity of alkaline phosphatase and (Ca2+ t Mg2+)-ATPase [9,10].
FEBS letters  •  1980  |  View Paper
Furthermore, co-treatment with leptin and vitamin D3 metabolites promoted ALP activity compared with either alone.
The Journal of Steroid Biochemistry and Molecular Biology  •  2020  |  View Paper
Further, it was found that the use of nHA and vitamin D3 resulted in increased expression of BGLAP and COLL I and reduced expression of ALP and RUNX2 in hADSCs for 21 days.
Materials science & engineering. C, Materials for biological applications  •  2019  |  View Paper
No significant postoperative change in vitamin D , calcium, or phosphate was observed, but alkaline phosphatase increased significantly (P < 0.001).
Archives of Osteoporosis  •  2019  |  View Paper
The meta-analysis suggested a significant reduction in alkaline phosphatase (−13.79 U/L; 95% CI, −22.13 to −5.45; I2 = 72%) following vitamin D supplementation.
Journal of dietary supplements  •  2019  |  View Paper
Our findings revealed after 1-year treatment of active vitamin D3 , PTH and ALP significantly decreased.
Osteoporosis International  •  2018  |  View Paper
The osteogenic markers, alkaline phosphatase , secreted phosphoprotein 1 (osteopontin), and bone gamma-carboxyglutamate protein (osteocalcin) are increased by 25(OH)D3 and 1α,25-(OH)2D3 in a dose-dependent manner.
Scientific reports  •  2017  |  View Paper
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