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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Tryptophan

Research Papers that Mention the Interaction

l-Tryptophan , but not d-tryptophan, inhibits human placental and intestinal alkaline phosphatases , but not those of liver and bone.
The Biochemical journal  •  1971  |  View Paper
The enzyme kinetics indicate that dl-tryptophan possesses chiral discrimination inhibition and l-tryptophan exhibits uncompetitive inhibition for ALP , compared with no obvious inhibition observed with its enantiomer.
Journal of materials chemistry. B  •  2013  |  View Paper
These studies suggest that the active site residues His and Trp at the E. coli enzyme positions 153 and 328, respectively, at least partially dictate the metal specificity of alkaline phosphatase.
The Journal of Biological Chemistry  •  2002  |  View Paper