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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Tretinoin

Research Papers that Mention the Interaction

ALP activity tests showed that ATRA or Ad-VEGF could enhance ALP activity in MEFs ( P<0.05), and ATRA had a stronger effect than Ad-VEGF; and the combined use of ATRA and Ad-VEGF significantly enhanced the ALP activity in MEFs ( P<0.05).
Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery  •  2020  |  View Paper
Results showed that ATRA enhanced the potential of BMP9 to induce the osteogenic markers, such as alkaline phosphates ( ALP ) and mineralization; but retinoic acid receptor a (RARa) inhibitor showed the reversal effects.
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie  •  2019  |  View Paper
Alkaline phosphatase and bone gamma carboxyglutamate protein (Bglap, Osteocalcin) were drastically reduced in RA treated cells and RA also reduced the protein levels of Runx2 and Osterix, key transcription factors for progression to a mature osteoblast.
PloS one  •  2013  |  View Paper
RA stimulated activity and expression of alkaline phosphatase (ALP) and upregulated activity of the ALP gene promoter.
Journal of Bone and Mineral Metabolism  •  2012  |  View Paper
In vitro, RA increased the NaB-induced increase in ALP activity.
Anti-cancer drugs  •  2006  |  View Paper
After treatment with RA (10(-6) M) for 4 d, there was a significant increase in the ALP activity of HPDL cells.
Journal of periodontal research  •  1998  |  View Paper
Treatment of IEC-6 cells with all-trans retinoic acid (RA) increased the levels of activity, protein and mRNA of L/B/K ALP , whereas enterocyte-specific proteins, including intestinal ALP, sucrase-isomaltase and glucose transporter-2, were not induced.
The Journal of nutrition  •  1998  |  View Paper
This was confirmed by nuclear run-on assays, which demonstrated a 2.5-fold increase in the abundance of ALP transcripts after 6 h of RA treatment.
Molecular endocrinology  •  1992  |  View Paper
RK in the presence of ATRA increased alkaline phosphatase ( ALP ) activity in a dose-dependent manner.
Journal of medicinal food  •  2014  |  View Paper
RA significantly upregulated gene expression and the activity of alkaline phosphatase in SHED and PDLSC.
Cell and Tissue Research  •  2010  |  View Paper
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