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Discover Supplement-Drug Interactions

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Last Updated: 2 months ago

Possible Interaction: Alkaline Phosphatase and Threonine

Research Papers that Mention the Interaction

In vitro, Thr supplement significantly increased cell numbers, protein content, the activities of GOT, GPT, AKP and Na+/K+-ATPase, and protein synthesis rate of enterocytes, and decreased LDH activity and ammonia content in cell medium (p<0.05).
The percent weight gain (PWG), specific growth rate, feed intake, … protein contents of hepatopancreas and intestine, folds heights, activities of alkaline phosphatase (AKP), γ- glutamyl transpeptidase and Na+/K+-ATPase in all intestinal segments, glutamate-…-BP2 gene expression in muscle, hepatopancreas and intestinal segments were significantly enhanced by Thr (…).
PloS one  •  2013  |  View Paper
The mutant AP with Thr at position 102 exhibited an ∼4000‐fold decrease in k cat along with a small decrease in K m. The decrease in catalytic efficiency of ∼2000‐fold was a much smaller drop than that observed when Ala or Gly were substituted at position 102.
Protein science : a publication of the Protein Society  •  2006  |  View Paper
Addition of threonine prevented the normal increase in alkaline phosphatase and reduced the production of extracellular protease by about 50%, suggesting that threonine blocked the sporulation process relatively early.
Journal of bacteriology  •  1979  |  View Paper