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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Threonine
Research Papers that Mention the Interaction
“In vitro, Thr supplement significantly increased cell numbers, protein content, the activities of GOT, GPT, AKP and Na+/K+-ATPase, and protein synthesis rate of enterocytes, and decreased LDH activity and ammonia content in cell medium (p<0.05).”
“The percent weight gain (PWG), specific growth rate, feed intake, … protein contents of hepatopancreas and intestine, folds heights, activities of alkaline phosphatase (AKP), γ- glutamyl transpeptidase and Na+/K+-ATPase in all intestinal segments, glutamate-…-BP2 gene expression in muscle, hepatopancreas and intestinal segments were significantly enhanced by Thr (…).”
Threonine Affects Intestinal Function, Protein Synthesis and Gene Expression of TOR in Jian Carp (Cyprinus carpio var. Jian)“The mutant AP with Thr at position 102 exhibited an ∼4000‐fold decrease in k cat along with a small decrease in K m. The decrease in catalytic efficiency of ∼2000‐fold was a much smaller drop than that observed when Ala or Gly were substituted at position 102.”
Trapping the tetrahedral intermediate in the alkaline phosphatase reaction by substitution of the active site serine with threonine“Addition of threonine prevented the normal increase in alkaline phosphatase and reduced the production of extracellular protease by about 50%, suggesting that threonine blocked the sporulation process relatively early.”
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