supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Sphingosine 1-Phosphate
Research Papers that Mention the Interaction
“Preincubation of human monocytes with S1P (1 μM; 16 h) resulted in an enhanced chemotaxis toward thrombin or to selective AP for PAR‐4 but not PAR‐1.”
Sphingosine‐1‐phosphate induces thrombin receptor PAR‐4 expression to enhance cell migration and COX‐2 formation in human monocytes“ S1P increased the amount of osteoprotegerin at both mRNA and protein levels, and increased the activity of alkaline phosphatase , leading to the mineralization.”
“These findings … that S1P activates the PI3K/Akt signaling pathway leading to the promotion of nuclear translocation of β-catenin in osteoblast-like cells, resulting in the upregulation of osteoptotegerin and osteoblast differentiation markers including alkaline phosphatase , probably relating to the inhibition of osteoclast formation and the mineralization, respectively.”
“Runx2 expression and ALP activity by BMP-2-stimulated C2C12 cells were enhanced by addition of either S1P or FTY.”
Sphingosine 1-phosphate receptor activation enhances BMP-2-induced osteoblast differentiation.
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback