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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Sphingosine 1-Phosphate

Research Papers that Mention the Interaction

Preincubation of human monocytes with S1P (1 μM; 16 h) resulted in an enhanced chemotaxis toward thrombin or to selective AP for PAR‐4 but not PAR‐1.
Journal of leukocyte biology  •  2014  |  View Paper
S1P increased the amount of osteoprotegerin at both mRNA and protein levels, and increased the activity of alkaline phosphatase , leading to the mineralization.
These findings … that S1P activates the PI3K/Akt signaling pathway leading to the promotion of nuclear translocation of β-catenin in osteoblast-like cells, resulting in the upregulation of osteoptotegerin and osteoblast differentiation markers including alkaline phosphatase , probably relating to the inhibition of osteoclast formation and the mineralization, respectively.
Bone  •  2013  |  View Paper
Runx2 expression and ALP activity by BMP-2-stimulated C2C12 cells were enhanced by addition of either S1P or FTY.
Biochemical and biophysical research communications  •  2012  |  View Paper