supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Serine
Research Papers that Mention the Interaction
“Exposure to D‐Ser not only suppressed several chondrocytic maturation markers, including alkaline phosphatase (ALP) activity, Ca2+ accumulation, nodule formation, and osteopontin expression, in rat chondrocytes, but also delayed chondral mineralization in mouse metatarsals.”
Interference with cellular differentiation by D‐serine through antagonism at N‐methyl‐D‐aspartate receptors composed of NR1 and NR3A subunits in chondrocytes“In vitro, SER significantly reduced osteogenic differentiation and mineralization of rat calvarial cells with concomitant reduction of osteoblast marker genes including alkaline phosphatase (Alpl), osterix (Sp7), and osteocalcin (Bglap).”
Serotonin Inhibits Osteoblast Differentiation and Bone Regeneration in Rats.“7.2.14 binding is abolished when the molecule is phosphorylated, presumably at a serine residue in exon 7, whereas treatment of material in cell lysates with alkaline phosphatase increases the intensity of the binding.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback