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Discover Supplement-Drug Interactions
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Last Updated: 5 years ago
drug:
Alkaline Phosphatase
supplement:
Quercetin
Research Papers that Mention the Interaction
“RT-PCR and real time PCR analysis showed that quercetin treatment induced an increase in the expression of osteopontin, BMP2, alkaline phosphatase and Runx2.”
Quercetin, a flavonoid, inhibits proliferation and increases osteogenic differentiation in human adipose stromal cells.“ Quercetin treatment significantly attenuated Ox-LDL-induced VSMC calcification, reduced ALP activity, down-regulated the expression levels of Msx2, BMP2 and Osterix, and up-regulated the expressions of vascular smooth muscle contractile proteins SMA and SM22a.”
“ Quercetin (10μM) inhibited cell proliferation, alkaline phosphatase (ALPL) activity and mineralization, down-regulating the expression of ALPL, collagen type I alpha 1 (COL1A1) and osteocalcin [bone gamma-carboxyglutamate protein (BGLAP)] osteoblastogenesis-related genes in MSC differentiating into osteoblasts.”
“We observed previously that quercetin can increase the activity of the differentiation markers alkaline phosphatase and dipeptidyl peptidase in Caco-2 colon cancer cells.”
“Furthermore, when the induction of HSPs was inhibited by the treatment of cells with quercetin , the stimulatory effects of Dex on AKP activity could still be inhibited completely by the heat shock treatment.”
“Results: Que significantly reduced circulating ALT, AST, ALP , and ameliorated LPS-induced histological alterations.”
Involvement of P450s and nuclear receptors in the hepatoprotective effect of quercetin on liver injury by bacterial lipopolysaccharide“Results The CCK-8 and ALP assays and ARS staining showed that quercetin significantly enhanced BMSC proliferation, ALP activity, and extracellular matrix production and mineralization, respectively.”
“Compared with mice treated with PFOA alone, simultaneous supplementation of Que significantly decreased serum levels of liver injury indicators alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase , lactate dehydrogenase and total bile acids.”
“ Quercetin and rutin also increased alkaline phosphatase activity by about 150 and 240% and demonstrated mineralization up to 110 and 200% respectively as compared to control (which was considered as 100%).”
“Furthermore, after cells had ceased to proliferate, quercetin reduced the activity of alkaline phosphatase , the level of expression of mRNA for osteocalcin, the rate of deposition of Ca(2+), and the formation of mineralized nodules, all of which are markers of osteoblast differentiation.”
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