Possible Interaction: Alkaline Phosphatase and Progesterone

“The presence of Alp significantly enhanced the effects of progesterone on cyclin B1 down-regulation, G2/M cell cycle arrest and induction of apoptosis (P < 0.01 for all).ConclusionOur findings suggest that cyclin B1 is a critical factor in proliferation and differentiation of hECs.”

“… AlkP … progesterone , and maximum activity was observed at concentration of 1 × 10−8 M. Both fenvalerate (1 × 10−6 M) and permethrin (1 × 10−6 M) …, but progesterone (1 × 10−8 M)-induced AlkP activity was significantly inhibited at 1 × 10−6 M concentration of fenvalerate and permethrin, respectively.”

“Typical AP treatment also induces a significant decrease in progesterone levels, which is maintained even after long-term drug administration (4–6).”

“Heterogeneous effects were observed on progesterone secretion and on the activity of cellular alkaline phosphatase.”

“ Progesterone , on the other hand, seems to augment the activity of acid phosphatase, ATPase, 5-nucleotidase, and esterase, and to inhibit the activity of alkaline phosphatase and succinic dehydrogenase.”

“Serum high-density lipoprotein cholesterol (HDL), alkaline phosphatase ALP ) and progesterone (P4) concentrations were significantly higher in the luteal phase than in the follicular phase (P<0.05).”

“Our results showed that cells cultured in the presence of progesterone had a 7% increase in the alkaline phosphatase activity when compared to untreated cells.”

“This is curious because progesterone may inhibit or decrease the estrogen-induced increase in uterine ALP in the rat,22 rabbit,' rhesus monkeys*g and human.”