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Last Updated: 2 years ago

Possible Interaction: Alkaline Phosphatase and Phenylalanine

Research Papers that Mention the Interaction

The ALP in all the groups was thermostable (65°C for 15 min) and was inhibited by L-phenylalanine , but no inhibition was seen with L-homoarginine in patients group only.
Pathology & Oncology Research  •  2009  |  View Paper
In the presence of L-phenylalanine , an ALP inhibitor, a strong decrease in fluorescence recovery was observed.
Chemistry, an Asian journal  •  2015  |  View Paper
1) Optimum pH of the enzyme was essentially identical through the species of the animals but the inhibition of L-phenylalanine was clearly demonstrable with human ALP but little with that of other animals.
Jikken dobutsu. Experimental animals  •  1977  |  View Paper
We found that, unlike the BLK‐ALP of … cell line, the activity of U‐2 OS ALP was thermostable, unaffected by … levamisole, but inhibited by L‐phenylalanine ; these properties are characteristic of the placental and/or placental‐like (… ALP) isoenzymes which are 98% homologous at the amino acid level.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1996  |  View Paper
In the fourth system the proportions of total ALP inhibited by phenylalanine and homoarginine, respectively, were assessed.
Prenatal diagnosis  •  1985  |  View Paper
However, we found that at pH 10.0, with p-nitrophenyl phosphate as the substrate, L-phenylalanine obviously inhibits the alkaline phosphatase isoenzyme from human placenta, whereas there is little if any inhibition of the isoenzyme from human intestine.
Clinical chemistry  •  1982  |  View Paper
The alkaline phosphatases of liver and bone are only minimally inhibited by L-phenylalanine , whereas intestinal and placental alkaline phosphatase and Regan isoenzyme are inhibited 77 to 79%.
Annals of the New York Academy of Sciences  •  1969  |  View Paper
Although biochemical assays suggested thatl-phenylalanine inhibited both alkaline phosphatase and HCO3−-activated ATPase, cytochemical studies indicated that there was marked inhibition of alkaline phosphatase revealing a specific HCO3−-activated ATPase on the inner aspect of the microvillus membrane.
The Histochemical Journal  •  2005  |  View Paper
Inhibition of alkaline phosphatase with L-phenylalanine , to the same extent as with Ca2+, increased MFP absorption with respect to controls but to a lower degree than with Ca2+.
Arzneimittel-Forschung  •  2003  |  View Paper
This alkaline phosphatase effect on desensitization was inhibited by L‐phenylalanine.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1994  |  View Paper
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