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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Panax Notoginseng
Research Papers that Mention the Interaction
“Additionally, PNS significantly increased the mRNA levels of alkaline phosphatase , core-binding factor a1, and bone sialoprotein while decreasing PPARγ2 mRNA levels.”
“We found that PNS markedly increased the mineralization of BMSCs by alizarin red S assays and stimulate alkaline phosphatase activity of these cells.”
Panax Notoginseng Saponins Promote Osteogenic Differentiation of Bone Marrow Stromal Cells Through the ERK and P38 MAPK Signaling Pathways“ PNS treatment increased ALP activity, Alizarin red S staining and mRNA level of ALP, Cbfa 1, OC, and BSP, whereas decreased the mRNA level and protein expression of PPARγ2 during osteogenic induction.”
“Alkaline phosphatase (ALP) assays and alizarin Red staining showed that PNS stimulated ALP activity and calcium deposition by BMSCs.”
“RT-PCR assays further showed that PNS augmented the increase in the mRNA levels of ALP , core-binding factor a1, and bone sialoprotein while decreasing the mRNA level of PPARΓ2.”
“The contraction force was decreased and the APD20, APD90 of normal AP were shortened in the presence of PNS 1 mg/ml, while the RP, APA and Vmax remained unchanged.”
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