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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Naringin

Research Papers that Mention the Interaction

Our in vivo results showed that Nar significantly reduced MTX-induced increases in serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin levels.
Bioscience reports  •  2020  |  View Paper
It … naringin markedly inhibited caspase‑3 activity, increased runt‑related … and transcription factor sp7 mRNA expression, promoted alkaline phosphatase activity and upregulated collagen I, peroxisome proliferator‑activated receptor (PPAR) γ2, neurogenic locus notch homolog …‑catenin and phosphorylated‑Rac‑α serine/threonine protein kinase protein expression in the SANFH rabbit.
Molecular medicine reports  •  2018  |  View Paper
In addition, naringin significantly increased the mRNA expression levels of OC, ALP , and collagen type I. Furthermore, naringin decreased the protein expression levels of PPARγ, and increased the expression levels of miR‑20a in the BMSCs.
Previous studies have demonstrated that naringin improves the activity levels of osteocalcin (OC) and alkaline phosphatase (ALP) in MC3T3‑E1 osteoblast precursor cells.
Molecular medicine reports  •  2015  |  View Paper
Meanwhile, 0.1 micromol x L(-1) naringin increased the ALP activity at 72 h (P < 0.05).
Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica  •  2009  |  View Paper
In this study, naringin a polymethoxylated flavonoid, was shown to enhance alkaline phosphatase activity, osteocalcin level, osteopontin synthesis and cell proliferation in primary cultured osteoblasts.
European journal of pharmacology  •  2008  |  View Paper
In the alkaline phosphatase activity assay, naringin at high concentration (0.1 µmol) significantly increased the activity up to 20%.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society  •  2006  |  View Paper
ALP expression was significantly promoted after stimulation of 100 μmol·L⁻¹ NAR and BMP-2 (P<0.05).
Hua xi kou qiang yi xue za zhi = Huaxi kouqiang yixue zazhi = West China journal of stomatology  •  2017  |  View Paper
Naringin increased the mineralization of BMSCs, as shown by Alizarin red S assays, and induced ALP activity.
American journal of translational research  •  2016  |  View Paper
We found that naringin dose-dependently increased ALP activity and Alizarin red S staining, and treatment at the optimal concentration (50 μg/mL) increased mRNA levels of osteogenic genes and Notch1 expression, while decreasing PPARγ2 mRNA levels.
Stem cells international  •  2016  |  View Paper
Biochemical studies revealed a significant (P < 0.05) dose dependant inhibition in serum alkaline phosphatase ALP ) and lactate dehydrogenase (LDH) levels by pretreatment of naringin.
Journal of biomedical research  •  2014  |  View Paper