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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Naringin
Research Papers that Mention the Interaction
“Our in vivo results showed that Nar significantly reduced MTX-induced increases in serum alanine aminotransferase, aspartate aminotransferase, alkaline phosphatase and total bilirubin levels.”
Naringin alleviates methotrexate-induced liver injury in male albino rats and enhances its antitumor efficacy in HepG2 cells“It … naringin markedly inhibited caspase‑3 activity, increased runt‑related … and transcription factor sp7 mRNA expression, promoted alkaline phosphatase activity and upregulated collagen I, peroxisome proliferator‑activated receptor (PPAR) γ2, neurogenic locus notch homolog …‑catenin and phosphorylated‑Rac‑α serine/threonine protein kinase protein expression in the SANFH rabbit.”
“In addition, naringin significantly increased the mRNA expression levels of OC, ALP , and collagen type I. Furthermore, naringin decreased the protein expression levels of PPARγ, and increased the expression levels of miR‑20a in the BMSCs.”
“Previous studies have demonstrated that naringin improves the activity levels of osteocalcin (OC) and alkaline phosphatase (ALP) in MC3T3‑E1 osteoblast precursor cells.”
“Meanwhile, 0.1 micromol x L(-1) naringin increased the ALP activity at 72 h (P < 0.05).”
[Effects of naringin on proliferation, differentiation and matrix mineralization of MC3T3-E1 cells].“In this study, naringin a polymethoxylated flavonoid, was shown to enhance alkaline phosphatase activity, osteocalcin level, osteopontin synthesis and cell proliferation in primary cultured osteoblasts.”
“In the alkaline phosphatase activity assay, naringin at high concentration (0.1 µmol) significantly increased the activity up to 20%.”
“ ALP expression was significantly promoted after stimulation of 100 μmol·L⁻¹ NAR and BMP-2 (P<0.05).”
[Effect of naringin combined with bone morphogenetic protein-2 on the proliferation and differentiation of MC3T3-E1 cells].“ Naringin increased the mineralization of BMSCs, as shown by Alizarin red S assays, and induced ALP activity.”
“We found that naringin dose-dependently increased ALP activity and Alizarin red S staining, and treatment at the optimal concentration (50 μg/mL) increased mRNA levels of osteogenic genes and Notch1 expression, while decreasing PPARγ2 mRNA levels.”
“Biochemical studies revealed a significant (P < 0.05) dose dependant inhibition in serum alkaline phosphatase ALP ) and lactate dehydrogenase (LDH) levels by pretreatment of naringin.”
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