Possible Interaction: Alkaline Phosphatase and Methionine

“OA-F2L (p < 0.05), M (p < 0.001) and H (p < 0.05) significantly reduced ALP levels, compared to DICLO.”

“Our result showed that in Saos-2 cells, formononetin and genistein (5 × 10−7 M ) treatment increased alkaline phosphatase activity by 33.0 ± 5.8% and 21.1 ± 4.0%.”

“RESULTS Osteocalcin and al aline phosphatase sy nthesis was significantly enhanced by 10⁻¹⁰ M to 10⁻ ⁵ M zo ledronate concentrations, whereas was dramatically decreased by higher drug concentrations.”

“Doxantrazole, AA-344, and M & B-22948 were intermediate in their inhibitory activities against alkaline phosphatase.”

“In vitro study shows that Dex over the dose of 10–8 M remarkably inhibited cellular osteogenesis, as represented by decreased cell viability, lessened ALP activity, and suppressed osteogenic protein expressions including ALP and OCN.”

“Our results showed that GRb1 at concentrations of 10−8 M and 10−6 M can increase alkaline phosphatase activity, mineralization and the expression of osteogenic related proteins, such as osteopontin and osteoprotegerin, while incubating rMSCs with osteogenic induction medium and GRb1.”

“Alkaline phosphatase ALP ) activity was decreased by 10−7 M Cd and DNA content and hydroxyproline content of osteoblastic cells were decreased by 10−5 M Cd.”

“It was found that M and P induced the dose- and time-dependent decrease of duodenal alkaline phosphatase (DAP) activity.”

“The presence of AHZ 10−7–10−5 M ) produced a remarkable increase of alkaline phosphatase activity and protein concentration in osteoblastic cells.”