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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Magnesium
Research Papers that Mention the Interaction
“We hypothesize that oxidative stress in AlP poisoning buffered the magnesium leading to a transient fall in magnesium and magnesium dependent GSH, resulting in increased susceptibility of oxygen free radical injury and accelerated lipid peroxidation.”
A critical evaluation of anti-peroxidant effect of intravenous magnesium in acute aluminium phosphide poisoning.“Early osteogenic marker … including osterix, alkaline phosphatase , and type I collagen were significantly … in MSCs under high concentration of magnesium , whereas late marker genes such as osteopontin, osteocalcin, and bone morphogenetic protein 2 were upregulated … statistical significance compared with those in normal differentiation medium containing 0.8 mM magnesium.”
“ Magnesium exposure profoundly enhanced alkaline phosphatase (ALP) gene expression and activity even at a relatively low magnesium concentration (2.5 mm).”
“We found that high concentrations of magnesium markedly inhibited the deposition of mineral matrix by SaOS-2 as well as the activity of alkaline phosphatase , a marker of osteoblast differentiation.”
“In the presence of magnesium , the dissociation rates of the complexes with C·AP andSMeG·AP are increased more than 20-fold, allowing each thymine DNA glycosylase to remove more than one uracil or thymine from C·U and SMeG·T mismatches in DNA.”
“Nevertheless, the influence of magnesium and calcium ions on the ATPase activity of alkaline phosphatase means that precautions must be taken when assaying for Ca2+-ATPase in the presence of alkaline phosphatase.”
“Metal ions other than zinc and magnesium were effective in modulating the activity of rat osseous plate alkaline phosphatase.”
Effect of pH on the modulation of rat osseous plate alkaline phosphatase by metal ions.“High concentrations of magnesium caused a pronounced inhibition on the labelling of the alkaline phosphatase band but had no effect on the phosphorylation of other proteins.”
“Thus, magnesium is influencing the expression of Cbfα1 and ALP associated with VC and may have the potential to serve as a role for VC in clinical situations.”
Magnesium prevents β-glycerophosphate-induced calcification in rat aortic vascular smooth muscle cells.“In the HOS-58 cells, the AP activity was statistically significant (P < 0.05) higher at a supplement of 5–10 mg of silver than of Ti-6 Al-4V at the same doses.”
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