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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Magnesium Cation
Research Papers that Mention the Interaction
“ Magnesium ions induced significant (P<0.05) increases in cell viability, alkaline phosphate activity and osteocalcin levels of human osteoblasts.”
Effect of magnesium ion on human osteoblast activity“The western blot results demonstrated that the introduction of Mg+ heightened the expressions of ALP and OCN.”
The osteoinduction of RGD and Mg ion functionalized bioactive zirconia coating“ Alkaline phosphatase from diabetic rats had a better affinity (K0.5 = 38 microM) for magnesium ions than controls (K0.5 = 91 microM).”
“Binding of magnesium ions to alkaline phosphatase induces conformational changes which activate the enzyme.”
Effect of membrane moiety and magnesium ions on the inhibition of matrix-induced alkaline phosphatase by zinc ions.“ Magnesium ions stimulated the activities at optimum concentrations of 10 mM for acid phosphatase and 2mM for alkaline phosphatase.”
“The alkaline phosphatase of the extracts was stimulated about 2.5-fold by the addition of 10−3m Mg++ or Zn++, whereas it was inhibited completely by 10−3 m ethylenediaminetetraacetic acid.”
“ Mg+ + retarded thermal inactivation of alkaline phosphatase.”
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