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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Alkaline Phosphatase and Leucine

Research Papers that Mention the Interaction

Two electrophoretically different variant forms of Regan alkaline phosphatase with a greater sensitivity to inhibition by L-leucine have since been described: the ‘Nagao isoenzyme’2, and a hepatoma-specific alkaline phosphatase3–5.
Nature  •  1976  |  View Paper
These preferential interactions of different leucine signals with different AP complexes may thus be the determining step sorting proteins from the trans-Golgi network to their final destinations.
The Journal of Biological Chemistry  •  2002  |  View Paper
Although species-specific differences in AP shape strongly influence the amplitude and the time course of ICa, L , divergence in L-type channel inactivation was found as well.
Pflügers Archiv  •  2000  |  View Paper
The incorporation of L‐[3H]leucine into alkaline phosphatase was significantly higher in bile duct‐ligated rats than in controls, 68,357 ± 7,144 vs. 19,297 ± 3,076 dpm per gm liver (p < 0.001) and 349 ± 36 vs. 104 ±17 dpm per gm protein (p < 0.001).
Hepatology  •  1983  |  View Paper
Inhibiting ALP , mutating the l-phosphotyrosine from the C-terminal to the middle of the phosphopentapeptides, or replacing l-leucine to d-leucine in the phosphopentapeptide abolishes the intranuclear assemblies of the pentapeptides.
Journal of the American Chemical Society  •  2021  |  View Paper