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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Leucine
Research Papers that Mention the Interaction
“Two electrophoretically different variant forms of Regan alkaline phosphatase with a greater sensitivity to inhibition by L-leucine have since been described: the ‘Nagao isoenzyme’2, and a hepatoma-specific alkaline phosphatase3–5.”
L-leucine, a specific inhibitor of a rare human placental alkaline phosphatase phenotype“These preferential interactions of different leucine signals with different AP complexes may thus be the determining step sorting proteins from the trans-Golgi network to their final destinations.”
Structural Requirements for Interactions between Leucine-sorting Signals and Clathrin-associated Adaptor Protein Complex AP3*“Although species-specific differences in AP shape strongly influence the amplitude and the time course of ICa, L , divergence in L-type channel inactivation was found as well.”
“The incorporation of L‐[3H]leucine into alkaline phosphatase was significantly higher in bile duct‐ligated rats than in controls, 68,357 ± 7,144 vs. 19,297 ± 3,076 dpm per gm liver (p < 0.001) and 349 ± 36 vs. 104 ±17 dpm per gm protein (p < 0.001).”
“Inhibiting ALP , mutating the l-phosphotyrosine from the C-terminal to the middle of the phosphopentapeptides, or replacing l-leucine to d-leucine in the phosphopentapeptide abolishes the intranuclear assemblies of the pentapeptides.”
Enzymatically Forming Intranuclear Peptide Assemblies for Selectively Killing Human Induced Pluripotent Stem Cells.
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