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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Kaempferol

Research Papers that Mention the Interaction

In SaOS-2 osteoblasts, treatment of kaempferol increased early and late osteogenic parameters significantly, including alkaline phosphatase ( ALP ) activity, collagen synthesis, and mRNA expression levels of Runx2, osterix, osteopontin and bone sialoprotein.
The Journal of nutritional biochemistry  •  2019  |  View Paper
BackgroundPrevious research revealed that luteolin could improve the activation of alkaline phosphatase (ALP) and osteocalcin in mouse osteoblasts.
BMC oral health  •  2019  |  View Paper
Furthermore, treatment with Kae in rat BMSCs enhanced mineralization, elevated ALP activity, increased the expression levels of Runx-2 and Osterix and increased the levels of p-S6K and decreased the levels of p-4E/BP1 and, consistent with its ability to promote osteoblast differentiation.
Molecular medicine reports  •  2019  |  View Paper
Similarly, kaempferol induced greater activation of alkaline phosphatase activity than control cells, and it enhanced the expression of chondrogenic marker genes, such as collagen type I, collagen type X, OCN, Runx2, and Sox9.
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association  •  2013  |  View Paper
In addition, treatment with kaempferol resulted in a significant elevation of alkaline phosphatase (ALP) activity, collagen content, and mineralization in the cells.
Biological & pharmaceutical bulletin  •  2009  |  View Paper
Luteolin (1 μM) caused a significant elevation of collagen content, alkaline phosphatase (ALP) activity, and osteocalcin secretion in the cells (P< 0.05).
Cell biology international  •  2007  |  View Paper
Cyclosporin A, verapamil, octreotide, kaempferol , daunomycin and genistein produced a concentration-dependent increase in ALP activity.
Cellular Physiology and Biochemistry  •  2000  |  View Paper
However, baicalein and luteolin inhibited ALP activity and flavone showed no effect.
Evidence-based complementary and alternative medicine : eCAM  •  2014  |  View Paper