Possible Interaction: Alkaline Phosphatase and Glutathione

“These effects were associated with a prevention of the GSH depletion and an inhibition in AP activity.”

“Diets supplemented with 600 or 900 mg/kg GSH significantly increased the enzymes activities of superoxide dismutase (SOD), lysozyme (LZM), alkaline phosphatase , and acid phosphatase, and significantly decreased the content of malondialdehyde.”

“ GSH co-administration increased serum concentrations of FSH, LH, testosterone, and levels of the testicular enzymes: LDH, ACP, and ALP.”

“Oral administration of GSH had significantly increased mean body weight gain, FE, PO activity, SOD activity, ACP activity, AKP activity, GPx activity and susceptibility to V. alginolyticus compared with those of the control group (p < .05).”

“In mouse bone marrow stromal cells, Glu and a GSH depleter significantly decreased ALP staining without affecting Oil Red O staining.”

“ Glutathione , an inhibitor of neutral SMase, completely blocked the NGF-induced augmentation of AP firing, whereas dithiothreitol, an inhibitor of acidic SMase, was without effect.”

“The high rate of generation of NADPH would be expected to reduce glutathione; reduced glutathione has been shown to inhibit alkaline phosphatase activity in these cells.”

“ Glutathione , an inhibitor of neutral SMase, completely blocked the NGF‐induced augmentation of AP firing, whereas dithiothreitol, an inhibitor of acidic SMase, was without effect.”

“On the other hand, the level of glutathione and the activity of alkaline phosphatase were reduced.”

“The data show that precursor availability and new biosynthesis of glutathione is enhanced by the exposure to WR-2721 + AP in vitro despite the differential modulation of the cellular glutathione status in the two cell lines.”