Possible Interaction: Alkaline Phosphatase and Glucose

“ ALP mRNA expression and activity were increased in HCASMCs cultured in high glucose-containing media , and the increases were suppressed by rosuvastatin.”

“The in vitro studies demonstrated that high glucose increased the expression of the osteoblast transcription factor core binding factor alpha subunit 1 (Cbfa1) and its downstream protein osteocalcin by 1.9-fold and 1.8-fold, respectively, and ALP activity by 1.5-fold.”

“ GLU (25 and 50 mM) markedly reduced ALP activity and mineralization on days 7 and 14 after differentiation.”

“The ALP activity decreased with glucose in a concentration-dependent manner ( P<0.05).”

“Although insulin levels at 0 minute were similar in both groups of subjects, insulin levels were significantly higher in the patients treated with AP at all times after the glucose load than in the healthy subjects.”

“Overall, we found that insulin secretion in response to a glucose load was significantly higher in the patients treated with AP , irrespective of NFG.”

“This assumption was further confirmed byin vitro experiments, in which AP was incubated with glucose resulting in decreased enzymatic activity.”

“Aseptic incubation with 25 mmol/L of D-glucose and APs rapidly reduced bone and placental AP activities before those of liver, kidney and intestinal enzymes.”

“The reduction in AP activity by incubation with glucose in vitro was reversed by the further addition of catalase.”

“vulgaris Cicla group), the AP treatments increased only glucose content.”

“High concentrations of glucose greatly increased the DFCs ALP activity in 1-7 days.”

“Cellular proliferation and alkaline phosphatase activity was significantly increased in the presence of glucose , however, the release of osteocalcin into culture media was similar in all three groups.”