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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alkaline Phosphatase
supplement:
Genistein
Research Papers that Mention the Interaction
“Our result showed that in Saos-2 cells, formononetin and genistein (5 × 10−7 M) treatment increased alkaline phosphatase activity by 33.0 ± 5.8% and 21.1 ± 4.0%.”
Formononetin prevents ovariectomy-induced bone loss in rats“ Genistein , but not estradiol or raloxifene, decreased the ratio of alkaline phosphatase mRNA to ectonucleotide pyrophosphatase phosphodiesterase 1 mRNA expression in osteoblasts.”
“Preincubation with genistein resulted in significant increases in both alkaline phosphatase (ALP) activity and carnitine uptake.”
“Pre-treatment of SaOS-2 cells with genistein and oestrogen not only enhanced PTH-induced ALP activity, but also attenuated PTH up regulation of RANKL mRNA expression and PTH down regulation of OPG mRNA expression.”
“The present results showed that genistein (10(-8) to 10(-6) m) induced alkaline phosphatase ( ALP ) activity and osteoprotegrin (OPG) expression in SaOS-2 cells in a dose-dependent manner.”
“Additionally, the anabolic effect of GS (10(-7) and 10(-6) mol/L) on the collage content and AKP activity were significantly enhanced in the presence of genistein (10(-7) or 10(-6) mol/L) .”
“Moreover, genistein increased alkaline phosphatase mRNA levels and activity, the osteoprotegerin:receptor activator of nuclear factor-kappaB ligand gene expression ratio, and the expression of TGFbeta1.”
“The diminished alkaline phosphatase up‐regulation was reversed by genistein , a general inhibitor of tyrosine kinases, and by piceatannol, an inhibitor for Syk kinase.”
“With respect to bone cell differentiation, tyrphostin A51 and genistein each significantly increased basal ALP specific activity and collagen synthesis in human bone cells.”
“ Genistein (5–75 mg/ml) dose-dependently stimulated AKP and DPDD with a maximal stimulation at 75 mg/ml by 158.6± 17.5% and 228.6±37.1% of control values, respectively (n=12, P<0.001).”
“Although the level of ALP mRNA was not consistently altered in response to the treatments, a marked increase in ALP activity was observed following 96 h treatment with genistein + MK‑4.”
“Furthermore, genistein + MK‑4 led to alterations in cell morphology to spindle or oval shapes, and increased the intensity of ALP staining.”
Genistein and menaquinone-4 treatment-induced alterations in the expression of mRNAs and their products are beneficial to osteoblastic MC3T3-E1 cell functions.
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