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Last Updated: 2 years ago

Possible Interaction: Alkaline Phosphatase and Genistein

Research Papers that Mention the Interaction

Our result showed that in Saos-2 cells, formononetin and genistein (5 × 10−7 M) treatment increased alkaline phosphatase activity by 33.0 ± 5.8% and 21.1 ± 4.0%.
Archives of pharmacal research  •  2010  |  View Paper
Genistein , but not estradiol or raloxifene, decreased the ratio of alkaline phosphatase mRNA to ectonucleotide pyrophosphatase phosphodiesterase 1 mRNA expression in osteoblasts.
Acta biochimica Polonica  •  2009  |  View Paper
Preincubation with genistein resulted in significant increases in both alkaline phosphatase (ALP) activity and carnitine uptake.
Biochemical pharmacology  •  2008  |  View Paper
Pre-treatment of SaOS-2 cells with genistein and oestrogen not only enhanced PTH-induced ALP activity, but also attenuated PTH up regulation of RANKL mRNA expression and PTH down regulation of OPG mRNA expression.
The present results showed that genistein (10(-8) to 10(-6) m) induced alkaline phosphatase ( ALP ) activity and osteoprotegrin (OPG) expression in SaOS-2 cells in a dose-dependent manner.
The British journal of nutrition  •  2006  |  View Paper
Additionally, the anabolic effect of GS (10(-7) and 10(-6) mol/L) on the collage content and AKP activity were significantly enhanced in the presence of genistein (10(-7) or 10(-6) mol/L) .
Wei sheng yan jiu = Journal of hygiene research  •  2004  |  View Paper
Moreover, genistein increased alkaline phosphatase mRNA levels and activity, the osteoprotegerin:receptor activator of nuclear factor-kappaB ligand gene expression ratio, and the expression of TGFbeta1.
Endocrinology  •  2004  |  View Paper
The diminished alkaline phosphatase up‐regulation was reversed by genistein , a general inhibitor of tyrosine kinases, and by piceatannol, an inhibitor for Syk kinase.
Microbiology and immunology  •  2001  |  View Paper
With respect to bone cell differentiation, tyrphostin A51 and genistein each significantly increased basal ALP specific activity and collagen synthesis in human bone cells.
Calcified Tissue International  •  1998  |  View Paper
Genistein (5–75 mg/ml) dose-dependently stimulated AKP and DPDD with a maximal stimulation at 75 mg/ml by 158.6± 17.5% and 228.6±37.1% of control values, respectively (n=12, P<0.001).
Cell and Tissue Research  •  1998  |  View Paper
Although the level of ALP mRNA was not consistently altered in response to the treatments, a marked increase in ALP activity was observed following 96 h treatment with genistein + MK‑4.
Furthermore, genistein + MK‑4 led to alterations in cell morphology to spindle or oval shapes, and increased the intensity of ALP staining.
Molecular medicine reports  •  2017  |  View Paper
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