supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Formononetin
Research Papers that Mention the Interaction
“Our result showed that in Saos-2 cells, formononetin and genistein (5 × 10−7 M) treatment increased alkaline phosphatase activity by 33.0 ± 5.8% and 21.1 ± 4.0%.”
Formononetin prevents ovariectomy-induced bone loss in rats“ Formononetin dose-dependently decreased ALP , IL-6, VEGF, BMP-2, OCN and Col I in OA Obs, while markedly increased ALP, VEGF, BMP-2, OCN and Col I in normal Obs.”
“In addition, the expression of osteogenic specific genes alkaline phosphatase ALP ), Run-related transcription factor 2(RUNX2), and osteocalcin (OCN) were up-regulated by FN treatment.”
“Moreover, FN enhanced the ALP level, calcium deposition and the expression of bone morphogenetic protein isoform (BMPs).”
Modulation of osteogenic and myogenic differentiation by a phytoestrogen formononetin via p38MAPK-dependent JAK-STAT and Smad-1/5/8 signaling pathways in mouse myogenic progenitor cells
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback