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Last Updated: 2 years ago

Possible Interaction: Alkaline Phosphatase and Fluorides

Research Papers that Mention the Interaction

The present paper describes observations that a mitogenic dose (i.e., 20 μM in BGJb medium) of fluoride significantly augments the phenytoin-dependent stimulation of normal human bone cell proliferation and alkaline phosphatase ( ALP ) activity in cell culture.
Calcified Tissue International  •  2004  |  View Paper
Fluoride stimulated [3H]thymidine incorporation and specific activity of alkaline phosphatase in human bone cells and chick bone cells but not in human skin cells.
Clinical orthopaedics and related research  •  1988  |  View Paper
Plasma alkaline phosphatase activity in chicks was elevated about twofold by added fluoride regardless of the dietary magnesium or calcium levels.
The Journal of nutrition  •  1963  |  View Paper
Activity of the osteogenic differentiation marker, alkaline phosphatase (ALP), also increased with fluoride after exposure for 1 week, increasing significantly at 1.0 ppm (P < .05).
The Journal of oral implantology  •  2013  |  View Paper
It was found that fluoride at 5 ppm concentration significantly stimulated cell proliferation and ALP activity between 24 and 48 hours after exposure whereas at higher concentrations (40 - 80 ppm), fluoride significantly inhibited cell growth and ALP activity after 48 hours (Student's t test).
The Southeast Asian journal of tropical medicine and public health  •  2003  |  View Paper
Channel activity was enhanced by adding fluoride (10 mM) or trifluoperazine (50 microM) whilst it was reduced after incubating with dibutyryl cAMP (50 microM) or alkaline phosphatase (250 U/ml).
Acta cientifica venezolana  •  1992  |  View Paper
Results suggested that excessive fluoride exposure might affect reproduction by altering the activities of alkaline phosphatase.
Biological Trace Element Research  •  2017  |  View Paper
Using primary rat osteoblasts, we demonstrated that fluoride significantly promoted osteoblasts proliferation and alkaline phosphate (ALP) expression as well as the mRNA expression levels of bone differentiation markers, including type I collagen (COL1A1), ALP and osteonectin.
Toxicology letters  •  2014  |  View Paper
Results showed that 1-year fluoride treatment obviously stimulated ALP activity and OCN level along with increase of bone fluoride concentration of rats, which indicated that fluoride obviously stimulated osteogenic action of rats.
Biological Trace Element Research  •  2012  |  View Paper
In addition, fluoride enhances alkaline phosphatase activity, a marker of osteoblastic differentiation, in a dose-dependent manner.
Research communications in molecular pathology and pharmacology  •  1999  |  View Paper
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