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Discover Supplement-Drug Interactions
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Last Updated: 4 years ago
drug:
Alkaline Phosphatase
supplement:
Epinephrine
Research Papers that Mention the Interaction
“Among various agents, epinephrine was recently found to increase ALP activity in differentiating MC3T3-E1 cells by stimulating alpha1 adrenergic receptors coupled to Gi proteins.”
Regulation of alkaline phosphatase activity by p38 MAP kinase in response to activation of Gi protein-coupled receptors by epinephrine in osteoblast-like cells.“In addition to its effect on cell replication, epinephrine also enhanced alkaline phosphatase (ALP) activity in these cells but had little effect on collagen synthesis and osteocalcin production.”
“ Abstract Alkaline phosphatases of serum, bone, intestinal mucosa, and milk, in glycine buffer, are inhibited to the extent of 70–100% by adrenaline , adernochrome, and other o -dihydroxyphenols with substitution at C-4, and by other o -quionones, at concentrations of 0.2−0.5 m M .”
Inhibition of alkaline phosphatase by adrenaline and related dihydroxyphenols and quinones.
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