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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Epigallocatechin Gallate

Research Papers that Mention the Interaction

EGCG (1 or … SCAPs, increased alkaline phosphatase activity and mineral deposition, and upregulated the expression of osteo-/odontogenic markers including dentin sialophosphoprotein (Dspp), dentin matrix protein-1 (Dmp-… Type I collagen (Col1), along with the elevated expression of BMP2 and phosphorylation level of Smad1/5/9 (p < 0.01).
Molecules  •  2021  |  View Paper
EGCG further increased ALP activity and mineralization.
EGCG increased ALP activity both 7 and 14 days after treatment.
In conclusion, EGCG can increase mRNA expression of BMP2 and subsequent osteogenic-related genes including Runx2, ALP , osteonectin and osteocalcin.
We found that EGCG , at concentrations of both 1 and 10 µmol/L, can increase mRNA expression of BMP2, Runx2, alkaline phosphatase (ALP), osteonectin and osteocalcin 48 h after treatment.
Molecules  •  2018  |  View Paper
Treatments with 2-10 μmol/L EGCG could significantly increase the mRNA expressions of COL Ⅰ and ALP with the highest values in 4-6 μmol/L EGCG treatment groups.
Zhonghua kou qiang yi xue za zhi = Zhonghua kouqiang yixue zazhi = Chinese journal of stomatology  •  2016  |  View Paper
Results demonstrated that EGCG treatment significantly inhibited the hypoxia-induced apoptosis in MSCs and promoted the level of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP-2), propeptide of type I procollagen I (PINP) and runt-related transcription factor 2 (RUNX2) in MSCs under either normoxia or hypoxia.
Molecular Biology Reports  •  2015  |  View Paper
EGCG also increased alkaline phosphatase activity, an early marker of osteoblastic differentiation.
The Journal of nutritional biochemistry  •  2007  |  View Paper
EGCG pretreatment significantly showed an anti‐lipidemic effect and protected the cell membrane … by the blocking of changes in serum levels of CK‐MB, LDH, ALP , ALT and troponin T. EGCG also maintained the redox balance by preventing … of the activity of SOD and CAT while limiting lipid peroxidation.
European journal of pharmacology  •  2017  |  View Paper
ALP activity was also significantly augmented upon EGCG treatment for 4 days, 7 days and 14 days.
In a murine bone marrow mesenchymal stem cell line, D1, the mRNA expressions of core binding factors a1 (Cbfa1/Runx2), osterix, osteocalcin, ALP increased after 48 h of EGCG treatment.
These results demonstrated that long-term treatment of EGCG increases the expressions of osteogenic genes, elevates ALP activity and eventually stimulates mineralization, in spite of its inhibitory effect on proliferation.
Osteoporosis International  •  2005  |  View Paper
Epigallocatechin gallate (EGCg; 10(-4) M) significantly inhibited alkaline phosphatase activity in the diaphyseal and metaphyseal tissues.
Biological & pharmaceutical bulletin  •  2001  |  View Paper
Results: The results showed that EGCG pretreatment significantly increased osteoblast viability and ALP and SOD activities when cells were exposed to DEX.
Front. Pharmacol.  •  2018  |  View Paper
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