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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alkaline Phosphatase
supplement:
Epigallocatechin Gallate
Research Papers that Mention the Interaction
“Cell proliferation and ALP activity of the hAOBs and hPDLCs were increased by EGCG treatment.”
Epigallocatechin gallate affects the proliferation of human alveolar osteoblasts and periodontal ligament cells, as well as promoting cell differentiation by regulating PI3K/Akt signaling pathway.“… EGCG (1 or … SCAPs, increased alkaline phosphatase activity and mineral deposition, and upregulated the expression of osteo-/odontogenic markers including dentin sialophosphoprotein (Dspp), dentin matrix protein-1 (Dmp-… Type I collagen (Col1), along with the elevated expression of BMP2 and phosphorylation level of Smad1/5/9 (p < 0.01).”
“ EGCG further increased ALP activity and mineralization.”
“ EGCG increased ALP activity both 7 and 14 days after treatment.”
“In conclusion, EGCG can increase mRNA expression of BMP2 and subsequent osteogenic-related genes including Runx2, ALP , osteonectin and osteocalcin.”
“We found that EGCG , at concentrations of both 1 and 10 µmol/L, can increase mRNA expression of BMP2, Runx2, alkaline phosphatase (ALP), osteonectin and osteocalcin 48 h after treatment.”
“Treatments with 2-10 μmol/L EGCG could significantly increase the mRNA expressions of COL Ⅰ and ALP with the highest values in 4-6 μmol/L EGCG treatment groups.”
“Results demonstrated that EGCG treatment significantly inhibited the hypoxia-induced apoptosis in MSCs and promoted the level of alkaline phosphatase (ALP), bone morphogenetic protein 2 (BMP-2), propeptide of type I procollagen I (PINP) and runt-related transcription factor 2 (RUNX2) in MSCs under either normoxia or hypoxia.”
“ EGCG also increased alkaline phosphatase activity, an early marker of osteoblastic differentiation.”
“ EGCG pretreatment significantly showed an anti‐lipidemic effect and protected the cell membrane … by the blocking of changes in serum levels of CK‐MB, LDH, ALP , ALT and troponin T. EGCG also maintained the redox balance by preventing … of the activity of SOD and CAT while limiting lipid peroxidation.”
Epigallocatechin‐3‐gallate prevents cardiac apoptosis by modulating the intrinsic apoptotic pathway in isoproterenol‐induced myocardial infarction“ ALP activity was also significantly augmented upon EGCG treatment for 4 days, 7 days and 14 days.”
“In a murine bone marrow mesenchymal stem cell line, D1, the mRNA expressions of core binding factors a1 (Cbfa1/Runx2), osterix, osteocalcin, ALP increased after 48 h of EGCG treatment.”
“These results demonstrated that long-term treatment of EGCG increases the expressions of osteogenic genes, elevates ALP activity and eventually stimulates mineralization, in spite of its inhibitory effect on proliferation.”
“ Epigallocatechin gallate (EGCg; 10(-4) M) significantly inhibited alkaline phosphatase activity in the diaphyseal and metaphyseal tissues.”
“Results: The results showed that EGCG pretreatment significantly increased osteoblast viability and ALP and SOD activities when cells were exposed to DEX.”
Epigallocatechin-3-Gallate Ameliorates Glucocorticoid-Induced Osteoporosis of Rats in Vivo and in Vitro
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