Possible Interaction: Alkaline Phosphatase and Emodin

“ Emodin also increased ALP , Alizarin Red‐mineralization activity, and the expression of osteoblastogenic gene markers, such as Runx2, osteocalcin (OCN), and ALP in mouse calvarial primary osteoblasts, as well as activated the p38‐Runx2 pathway, which enhanced osteoblast differentiation.”

“The alkaline phosphatase (ALP) activity in KB cells increased upon treatment with aloe-emodin when compared to controls.”

“ Emodin enhanced the differentiation and mineralization of MC3T3-E1 cells, as evidenced by elevated alkaline phosphatase activity and increased number of mineralized nodules.”

“RESULT Compared to the model group, Em din tr eatment resulted in significant reductions in serum total bilirubin (TBiL), direct bilirubin (DBiL), alanine aminotransferase (ALT) and aspartate aminotransferase (AST), alk aline phosphatase (A LP), total bile acid (TBA) (P < 0.01 or P < 0.05).”

“ Emodin pretreatment …, and ALP ; increased the levels of ALB; alleviated hepatocellular damage and apoptosis; attenuated the exhaustion of GSH and SOD and the accumulation of MDA; and …, including nuclear factor erythroid 2-related factor 2 (Nrf2), heme oxygenase 1 (HO-1), and NAD(P)H quinone dehydrogenase 1 (NQO1).”

“This finding suggested that aloe-emodin induced the synthesis of matrix proteoglycans and increased the activity of alkaline phosphatase.”