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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Edetic Acid

Research Papers that Mention the Interaction

We found that the endogenous alkaline phosphatase in human peripheral blood mononuclear cells was incompletely inhibited by EDTA or L-cysteine.
Journal of immunological methods  •  1984  |  View Paper
Such thermostability of human placental ALP almost disappeared after treatment with EDTA , suggesting that the divalent metal ions were required for the thermostability.
Jikken dobutsu. Experimental animals  •  1977  |  View Paper
AP is functionally blocked by ethylenediaminetetraacetic acid (EDTA), which allows the repeated use of AP conjugates in immunohistochemistry with different substrates.
Histochemistry and Cell Biology  •  1998  |  View Paper
MVM alkaline phosphatase activity was shown to be inhibitable in a dose- and time-dependent manner by EDTA present in the storage buffer.
Biochimica et biophysica acta  •  1994  |  View Paper
Alkaline phosphatases from different tissues show different susceptibilities to the irreversible inactivation by EDTA.
Biochimica et biophysica acta  •  1967  |  View Paper
Alkaline phosphatase activity and transport of Pi in brush border membrane vesicles were also compared in the presence of EDTA or Zn2+ at concentrations which inhibit alkaline phosphatase activity.
Pflügers Archiv  •  2004  |  View Paper
Na2 EDTA creates, on the other hand, poor preservation of alkaline phosphatase probably due to the fact that this chelate contrary to the other chelates removes the essential metal from the protein, leaving an unstable enzyme molecule which undergoes denaturation.
Histochemistry  •  2004  |  View Paper
Most metabolites and enzymes did not show any variation, but significant decreases in electrolytes, alkaline phosphatase , acetylcholinesterase, bile acids, fructosamine and albumin were found when EDTA was used.
Veterinary journal  •  2004  |  View Paper
Irreversible inhibition of alkaline phosphatase by EDTA at concentrations of 1.0mM and above has been observed.
Analytical biochemistry  •  2002  |  View Paper
This pI change was inhibited by EDTA , an inhibitor of alkaline phosphatase.
FEBS letters  •  1991  |  View Paper
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