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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Daidzein
Research Papers that Mention the Interaction
“Finally, we demonstrated that daidzein stimulated Col I, Runx2, and ALP expression, while these effects were significantly blocked by the BMP signaling inhibitor noggin.”
“Here, we … that daidzein stimulated cell proliferation and differentiation of osteoblasts, demonstrated … upregulation of XTT activity, enhancement of alkaline phosphatase ( ALP ) activity, and upregulation of osteoblast-specific marker genes, including Runt-related transcription factor 2 (Runx2) and Smad1, as well as up-regulation of Runx2 and Smad1 protein expression.”
Daidzein promotes proliferation and differentiation in osteoblastic OCT1 cells via activation of the BMP-2/Smads pathway.“ ALP level decreased progressively as the dose of DAI increased, but there was no significant difference between groups (P>0.05).”
“Finally, we demonstrated that daidzein stimulated Col I, Runx2, and ALP expression, while these effects were significantly blocked by the BMP signaling inhibitor noggin.”
“Here, we … that daidzein stimulated cell proliferation and differentiation of osteoblasts, demonstrated by upregulation of XTT activity, enhancement of alkaline phosphatase ( ALP ) activity, and upregulation of osteoblast-specific marker genes, including Runt-related transcription factor 2 (Runx2) and Smad1, as well as upregulation of Runx2 and Smad1 protein expression.”
Daidzein promotes osteoblast proliferation and differentiation in OCT1 cells through stimulating the activation of BMP-2/Smads pathway.“ Daidzein and genistein alone did not affect cell growth but increased alkaline phosphatase ( ALP ) activity.”
“ Alp and Igf1 genes were down-regulated in callus after daidzein and E(2) compared with 4-MBC (week 5).”
“ Daidzein increased ALP activity, osteocalcin secretion, and mineralization, while E2 increased only ALP activity.”
“In addition, daidzein (2-100 microM) increased the alkaline phosphatase activity and osteocalcin synthesis (P<0.05) of osteoblasts by about 1.4- and 2.0-fold, respectively.”
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