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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alkaline Phosphatase
supplement:
Cysteine
Research Papers that Mention the Interaction
“ Cysteine increased the ALP activity and the phosphorylation of extracellular signal-regulated kinase.”
“ Cysteine increased the levels of alkaline phosphatase ( ALP ) and 17β-estradiol in the serum of the OVX mice and improved the bone mineral density in the OVX mice.”
Cysteine Prevents Menopausal Syndromes in Ovariectomized Mouse“Like kidney ALP, this ALP was markedly inhibited by 0.5 mmol/l L-cysteine.”
“Thus, there are two sites on human liver and placental alkaline phosphatase that interact with L-cysteine ; a Mg2+-binding site, which results in activation, and a site that involves one or both of the bound Zn2+ ions and results in inactivation.”
“Decreased inhibitory effect by cysteine and cyanide on alkaline phosphatase has been observed in the later passages.”
“The results indicate that cysteine inhibits alkaline phosphatase by chelation of the Zn atom at the active site of the enzyme.”
“ Cysteine or levamisole was used to inhibit alkaline phosphatase activity.”
Cytochemical localization of Na+-K+-ATPase in rat type II pneumocytes.“The chondrocytic alkaline phosphatase is inhibited irreversibly by Be2+, EDTA, EGTA, ethane-1-hydroxydiphosphonate, dichloromethane diphosphonate, L-cysteine , phenyl-methylsulfonyl fluoride, N-ethylmaleimide and iodoacetamide.”
“The mitochondrial extracts contained alkaline phosphatase activity that was inhibited by L-cysteine and dithiothreitol.”
“ Cysteine (0.1 mM) altered the D37 of both AP and ATPase to 21 and 87 krads, respectively, whereas 4A1N (0.1 mM) changed the D37 of AP to 180 and ATPase to 148 krads.”
“The results prove that acid phosphatase plays an important part in keratinization and that the earlier reports of absence of alkaline phosphatase in squamous epithelium were due to the inhibitory effect of cysteine.”
Alkaline and acid phosphatase activity in postauricular skin and cholesteatoma epithelium.
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