Possible Interaction: Alkaline Phosphatase and Copper

“In contrast to its effect on cell attachment, GHK Cu coating slightly inhibited the basal and 1,25(OH)2D-induced stimulation of ALP activity or osteocalcin production in rat and human osteoblastic cells.”

“Thus, the results indicated that copper could promote AKP activity and collagen production by chondrocytes.”

“Both Cd and Cu exposures decreased the activity of ALP , although they increased the activities of ALT and AST.”

“Supplementation of 450 mg/kg copper increased alkaline phosphatase and gamma glutamyl transpeptidase activities (p < 0.05), malondialdehyde, and high-density lipoprotein levels (p < 0.01) but decreased alanine aminotransferase and lactate dehydrogenase activities (p < 0.01).”

“Culture with copper (10(-7) - 10(-4) M) caused a significant decrease in alkaline phosphatase activity in the diaphyseal and metaphyseal tissues, while calcium and DNA contents in these tissues were not significantly changed.”

“The effects of zinc in increasing calcium content and alkaline phosphatase activity in the diaphyseal and metaphyseal tissues were significantly weakened in the presence of copper (10(-4) M).”

“The activity of GP and AP in the lower jejunum tended to decrease in pigs fed Cu (P less than .11, P less than .08, respectively).”

“In vitro, the presence of 10(-6) M Cu suppressed enzyme activities in the tissues examined, with a few exceptions such as AcP in ovaries and gut, AlP in liver, gills, gut, and testes, and LDH in liver.”

“Alkaline phosphatase ALP ) activity was decreased by Cd (5.0 microM and above) or Cu (10 microM and above) in diaphysis.”

“While in vivo exposure to 5 and 7.5 mg/l copper resulted in the activation of alkaline phosphatase in the kidney, the activity of this enzyme in the liver was inhibited at the highest concentration.”

“The acid and alkaline phosphatase activity of the uterus was significantly (p less than .01) increase by the copper device.”