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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Cobalt
Research Papers that Mention the Interaction
“The results revealed that cobalt ions increased the expression of angiogenic markers, with the effects being stronger … were added as a dissolved salt in cell medium as compared to incorporation into CaP. Cobalt ions generally … ALP activity, the expression of osteogenic genes, and … of mineralization, regardless of delivery method.”
Combinatorial incorporation of fluoride and cobalt ions into calcium phosphates to stimulate osteogenesis and angiogenesis.“Furthermore, cobalt ions significantly inhibit osteoblast function as demonstrated by reduced alkaline phosphatase activity and calcium deposition.”
“ Cobalt was toxic to both cell lines and inhibited the production of type-I collagen, osteocalcin and alkaline phosphatase.”
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