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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Cobalt

Research Papers that Mention the Interaction

The results revealed that cobalt ions increased the expression of angiogenic markers, with the effects being stronger … were added as a dissolved salt in cell medium as compared to incorporation into CaP. Cobalt ions generally … ALP activity, the expression of osteogenic genes, and … of mineralization, regardless of delivery method.
Biomedical materials  •  2016  |  View Paper
Furthermore, cobalt ions significantly inhibit osteoblast function as demonstrated by reduced alkaline phosphatase activity and calcium deposition.
Journal of orthopaedic research : official publication of the Orthopaedic Research Society  •  2009  |  View Paper
Cobalt was toxic to both cell lines and inhibited the production of type-I collagen, osteocalcin and alkaline phosphatase.
The Journal of bone and joint surgery. British volume  •  1997  |  View Paper