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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Alkaline Phosphatase
supplement:
Ascorbate
Research Papers that Mention the Interaction
“After screening extensively factors in plant extracts that increase alkaline phosphatase activity, an osteoblastic differentiation marker protein in mouse calvarial osteoblast MC3T3-E1 cells, GnafC derived from Gnaphalium affine, was found to significantly enhance the alkaline phosphatase (ALPase) activity in a synergistic manner with ascorbate.”
Isolation of GnafC, a Polysaccharide Constituent of Gnaphalium affine, and Synergistic Effects of GnafC and Ascorbate on the Phenotypic Expression of Osteoblastic MC3T3-E1 Cells“ Ascorbate also induces alkaline phosphatase activity in mature cells but not in immature cells.”
“Both alkaline phosphatase activity and type X collagen mRNA levels began to increase within 24 h of ascorbate treatment; by 9 days, the levels of both alkaline phosphatase activity and type X collagen mRNA were 15-20-fold higher than in non-ascorbate-treated cells.”
“Aromatic residues of bovine kidney alkaline phosphatase appear to be involved in the interaction with ascorbate , as shown by the strong quenching of intrinsic fluorescence and absorption.”
The relationship between the optical properties and the kinetic behaviour of ascorbate-inhibited alkaline phosphatase.
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