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Discover Supplement-Drug Interactions

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Last Updated: 3 years ago

Possible Interaction: Alkaline Phosphatase and Ascorbate

Research Papers that Mention the Interaction

After screening extensively factors in plant extracts that increase alkaline phosphatase activity, an osteoblastic differentiation marker protein in mouse calvarial osteoblast MC3T3-E1 cells, GnafC derived from Gnaphalium affine, was found to significantly enhance the alkaline phosphatase (ALPase) activity in a synergistic manner with ascorbate.
Bioscience, biotechnology, and biochemistry  •  2003  |  View Paper
Ascorbate also induces alkaline phosphatase activity in mature cells but not in immature cells.
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research  •  1992  |  View Paper
Both alkaline phosphatase activity and type X collagen mRNA levels began to increase within 24 h of ascorbate treatment; by 9 days, the levels of both alkaline phosphatase activity and type X collagen mRNA were 15-20-fold higher than in non-ascorbate-treated cells.
The Journal of biological chemistry  •  1989  |  View Paper
Aromatic residues of bovine kidney alkaline phosphatase appear to be involved in the interaction with ascorbate , as shown by the strong quenching of intrinsic fluorescence and absorption.
The Biochemical journal  •  1986  |  View Paper