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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Alkaline Phosphatase
supplement:
Andrographolide
Research Papers that Mention the Interaction
“Here we report the promoting effects of AP on the differentiation of mouse pre-osteoblastic (MC3T3-E1) cells by increasing the expression and activity of alkaline phosphatase (ALP), an osteoblastic gene-specific marker.”
Andrographolide modulates OPG/RANKL axis to promote osteoblastic differentiation in MC3T3-E1 cells and protects bone loss during estrogen deficiency in rats.“We observed that 200 mg/kg andrographolide significantly decreased the level of alanine transaminase, aspartate aminotransferase, alkaline phosphatase , γ-glutamyltranspeptidase, total bilirubin, and total bile acid in the blood.”
Andrographolide impairs alpha-naphthylisothiocyanate-induced cholestatic liver injury in vivo“Results: Results showed that AP of 4.46 and 8.92 µM, especially 8.92 µM was beneficial to osteogenic differentiation by upregulating ALP activity and expression of osteogenic related genes (P<0.05).”
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