Possible Interaction: Alendronate and Calcium Supplement

“ResultsSerum levels of calcium decreased at day 28 in the alendronate group.”

“These results show that continuous treatment for 9 months with calcitriol or calcium in combination with alendronate significantly increases both vertebral and femoral neck density (from 3.8% to 4.5% and from 0.61% to 2.36% respectively) in osteopenic postmenopausal women.”

“Following bedrest in the alendronate group, urinary calcium rose to 121 ± 50 mg/day, a value less than that in the placebo group before or during bedrest.”

“Moreover, the alendronate group had a lower urinary calcium (75 ± 41 mg/day) and saturation of calcium oxalate and calcium phosphate.”

“Treatment with alendronate decreased both urinary markers of bone resorption (pyridinolines, hydroxyproline, and calcium ) and serum markers of bone formation (osteocalcin and alkaline phosphatase) in a dose-dependent fashion.”

“Various doses of alendronate or clodronate soon produced a significant fall in plasma calcium ( Ca ), accompanied by a dose‐dependent decrease in the fasting urinary Ca/creatinine ratio, taken as a reflection of bone resorption.”

“Results Alendronate treatment resulted in a decrease in iCa in all 12 cats.”

“However, when compared with calcium or low dosages of salmon calcitonin (salcatonin) therapy in women with postmenopausal osteoporosis, alendronate induced a sustained increase in bone mass during therapy that was not seen with the comparator.”

“In the stone-formers, a short-term course of alendronate treatment corrected fasting urinary calcium (0.14+/-0.06 to 0.06+/-0.04 mg Ca/mg Cr, P=0.001) and marginally reduced 24-h urinary calcium by 48 mg/day (P=0.06).”

“In the presence of calcium , pamidronate and alendronate were toxic to the cells, with pamidronate being more toxic than alendronate.”

“At the same time we found that short term treatment with alendronate decreased urinary calcium in these subjects.”