supp.ai
Discover Supplement-Drug Interactions
Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago
drug:
Aldosterone
supplement:
Trypsin
Research Papers that Mention the Interaction
“Stimulation of aldosterone by a serine protease, trypsin , was first reported in 1982, although the mechanism of this effect was unclear.”
Aldosterone secretion by the rat adrenal cortex is stimulated by the activation of protease-activated receptor 1.“Preincubation of viable whole glandular tissue with trypsin significantly enhanced aldosterone output and eliminated the trypsin-releasable 18-OH-DOC pool in IEF gels of solubilized inner zone membranes.”
“On the other hand, stimulation of short-circuit current by aldosterone or pyruvate (added to substrate-depleted, aldosterone-repleted bladders) was substantially reduced by prior trypsinization of the apical surface.”
Help us improve supp.ai, we'd love to hear your feedback: Submit Feedback