“Compared to saline-treated SD rats, plasma aldosterone increased by ~50 pg/mL after infusing S1P.”
“Here, we investigated whether sphingosine-1-phosphate S1P ), which has previously been linked to obesity, increases aldosterone release.”
“ S1P induced a short-lasting increase in plasma aldosterone in obese, but not in lean SHRs.”
“We conclude that S1P is a local regulator of aldosterone production.”