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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aldosterone
supplement:
Riboflavin
Research Papers that Mention the Interaction
“Previous studies in rats have demonstrated that 1) aldosterone enhances biosynthesis of renal flavin coenzymes; 2) riboflavin analogs inhibit the synthesis of aldosterone ; and 3) adriamycin inhibits flavin coenzyme biosynthesis.”
Adriamycin-induced increase in serum aldosterone levels: effects in riboflavin-sufficient and riboflavin-deficient rats.“These studies are based on our previous observation that aldosterone enhances the biosynthesis of renal flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD) from riboflavin, and that FMI and HEI competitively inhibit conversion of riboflavin to FMN and reabsorption of Na + in the kidney of adrenalectomized rats.”
“These data strongly suggest that the enhanced synthesis of renal FMN and FAD may be a causative factor in the increased reabsorption of Na(+) as a result of aldosterone ; and, consequently, riboflavin analogues may function as a novel class of antimineralocorticoids.”
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