Possible Interaction: Aldosterone and Progesterone

“The results showed that women in the luteal phase of the menstrual cycle exhibited significantly higher morning concentrations in salivary aldosterone than men and women in the follicular phase.”

“In humans, rats, alligators and frogs, progesterone antagonizes activation of the MR by aldosterone , the physiological mineralocorticoid in terrestrial vertebrates.”

“ Progesterone has high affinity for the MR and is a natural antagonist of aldosterone.”

“At a concentration of 100 nmol/l, progesterone , 17alpha-OH-P and 20alpha-DH-P inhibit nearly 75, 40 and 35% of the transactivation by aldosterone respectively.”

“In vivo, progesterone administration, like dietary sodium restriction, caused a significant increase in PRA (p < or = 0.043) and plasma aldosterone (p < or = 0.009), with no change in plasma corticosterone.”

“Thus, chronic progesterone administration apparently does not directly influence aldosterone secretion, but rather acts indirectly to increase aldosterone by mechanisms similar to sodium restriction.”

“The sex steroid progesterone bound with an affinity (ki < 0.01 nM) even higher than that of aldosterone to the human mineralocorticoid receptor and effectively antagonized the effect of aldosterone via the human mineralocorticoid receptor in functional co-transfection assays.”

“4 Nicolini, G., Balzan, S., Morelli, L. et al. (2014) LH, progesterone , and TSH can stimulate aldosterone in vitro: a study on normal adrenal cortex and aldosterone producing adenoma.”

“Diagnosis of PHA in pregnancy is difficult due to the antagonistic effect of progesterone on aldosterone , physiological increase of aldosterone release during gestation and frequent normokalaemic clinical course.”

“ Aldosterone increased after in vitro stimulation with LH (5/12 adenoma, 1/7 normal cells), progesterone (4/5 adenoma, 5/6 normal cells), and TSH (3/5 adenoma and 3/5 normal cells).”

“However, we have recently shown that progesterone inhibits aldosterone production of both the native and the chimeric CYP11B1/CYP11B2 gene isoforms of aldosterone synthase in an in vitro study.”