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“Indeed, they found that the anti-inflammatory actions of paricalcitol may depend on the inhibition of TGF-α/ADAM17/EGFR pathway stimulated by aldosterone.”
“In conclusion, our data suggest that the anti-inflammatory actions of paricalcitol in tubular cells could depend on the inhibition of TGF-α/ADAM17/EGFR pathway in response to aldosterone , showing an important mechanism of VDRAs action.”