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Last Updated: 2 years ago

Possible Interaction: Aldosterone and Oxytocin

supplement:

Oxytocin

Research Papers that Mention the Interaction

The increase in WR frequency induced by elevated plasma osmolality was augmented by injection of aldosterone or angiotensin-I. In vivo water uptake, measured in a water bath, was increased by an NaCl or oxytocin injection, but not by aldosterone.
The Journal of experimental zoology  •  1999  |  View Paper
In conclusion, we have shown that concomitant administration of aldosterone and oxytocin increased the rate of excretion of Na+ in two different preparations, which supports the idea of an interaction between the steroid and oxytocin to promote Na+ loss.
The possibility of an interaction between oxytocin and aldosterone to influence renal Na+ excretion was investigated in Inactin‐anaesthetized male Sprague‐Dawley rats.
aldosterone … oxytocin was associated with a significantly (P < 0.01) increased Na+ excretion rate from a peak pretreatment value of 6.8 +/− 0.7 mumol/min … value of 11.5 +/− 1.1 mumol/min by 1 h 40 min after the start of treatment in Adx rats (n = 7).
Experimental physiology  •  1994  |  View Paper
Oxytocin enhances the effects of aldosterone in blood from intact...
Archives internationales de physiologie et de biochimie  •  1963  |  View Paper
The sodium retaining activity of 0.5 and 1.0 µg of aldosterone was abolished when used in combination with 2.5 and 5.0 mu oxytocin.
The American journal of physiology  •  1960  |  View Paper
Lower doses of aldosterone are needed if oxytocin is injected simultaneously.
General and comparative endocrinology  •  1964  |  View Paper
Besides showing that oxytocin affects the output of electrolytes by a mechanism different from renin, these experiments would appear to support the assumption that oxytocin enhances the elimination of sodium by counteracting the effect of aldosterone.
It has been shown that a dose range of 2.5–5 mu of oxytocin neutralizes the sodium-retaining activity of 1 µg of aldosterone2.
Nature  •  1963  |  View Paper