Possible Interaction: Aldosterone and Oleic Acid

“Both, glucocorticoids (dexamethasone, cortisol … mineralocorticoids (deoxycorticosterone and aldosterone ) as well as the estrogen β-estradiol and … enhanced the extent of Δ9 desaturation to oleic acid of the saturated precursors, whereas only the two mineralocorticoids affected the incorporation … the exogenous acid into total cellular lipids, thus promoting a little stimulation.”

“Within the phosphatidylethanolamine subclass, pretreatment of rats with aldosterone decreased the content of monounsaturated fatty acids (predominantly oleic and palmitoleic acid) and of n-3 fatty acids, and increased the content of saturated fatty acids (palmitic acid).”

“Addition of oleic or linolenic acid to washed cells inhibited both aldosterone and corticosterone production, although cells from hypoxic 7-day-old rats were less sensitive.”

“Pretreatment of the rats with aldosterone led to a significant decrease in the percent distribution of palmitic, arachidonic, docosapentaenoic and docosahexenoic acids, with a concomitant increase in palmitoleic, oleic and linoleic acids in plasma and liver homogenates, microsomes and cytosol fractions.”