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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aldosterone
supplement:
Leucine
Research Papers that Mention the Interaction
“In the normal adult during the … the colon absorbs approximately 1.5 L of fluid, … influence of aldosterone increases up to 5 to 6 L. Diarrhoea occurs when secretion exceeds absorptive processes by either … overwhelming colonic salvage or salvage being impaired by reduced colonic absorption or increased colonic secretion.”
Advances in Understanding Colonic Function“Administration of aldosterone (2 μg/100 g body wt) to adrenalectomized rats increased3H leucine incorporation into trichloroacetic acid insoluble fractions of crude homogenates of cortical slices by 15.5±0.4% and of medullary slices by 53.5±1.3%.”
Effect of aldosterone on incorporation of amino acids into renal medullary proteins“GR occupancy by corticosterone, the highly selective type II (glucocorticoid) receptor agonist RU28362, or high doses of aldosterone lowers incorporation; when this effect is blocked by coincubation with the glucocorticoid antagonist RU486, aldosterone , but not corticosterone, markedly elevates leucine incorporation, indicating a specific mineralocorticoid effect via MR.”
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