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Discover Supplement-Drug Interactions

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Last Updated: 2 years ago

Possible Interaction: Aldosterone and Leucine



Research Papers that Mention the Interaction

In the normal adult during the … the colon absorbs approximately 1.5 L of fluid, … influence of aldosterone increases up to 5 to 6 L. Diarrhoea occurs when secretion exceeds absorptive processes by either … overwhelming colonic salvage or salvage being impaired by reduced colonic absorption or increased colonic secretion.
Journal of pediatric gastroenterology and nutrition  •  2009  |  View Paper
Administration of aldosterone (2 μg/100 g body wt) to adrenalectomized rats increased3H leucine incorporation into trichloroacetic acid insoluble fractions of crude homogenates of cortical slices by 15.5±0.4% and of medullary slices by 53.5±1.3%.
The Journal of Membrane Biology  •  2005  |  View Paper
GR occupancy by corticosterone, the highly selective type II (glucocorticoid) receptor agonist RU28362, or high doses of aldosterone lowers incorporation; when this effect is blocked by coincubation with the glucocorticoid antagonist RU486, aldosterone , but not corticosterone, markedly elevates leucine incorporation, indicating a specific mineralocorticoid effect via MR.
Endocrinology  •  1996  |  View Paper