Possible Interaction: Aldosterone and Epinephrine

“Splanchnic nerve activation as well as perfusion with EPI provoked a significant release of cortisol, aldosterone and androstenedione.”

“ Aldosterone tertile was significantly associated with increasing plasma levels of NTproBNP (N-terminal pro-B-type natriuretic peptide), BNP (B-type natriuretic peptide), epinephrine , and endothelin-1 (P <or= 0.010), but not ANP (atrial natriuretic peptide).”

“ Adrenal surgery reduced plasma concentrations of atrial natriuretic factor and aldosterone concomitant with the elevation in urinary sodium excretion, plasma renin activity and urinary sodium-to-potassium ratio.”

“In separate experiments, epinephrine lowered serum K, raised serum Na, raised plasma renin activity and, usually lowered plasma aldosterone concentrations.”

“Those treated with both LPS and aldosterone showed reversible vestibular dysfunction after the intratympanic injection of epinephrine.”

“They do produce aldosterone ; however, it is produced at reduced levels correlating with adrenal size.”

“The results of this study indicate that adrenaline influences the steroidogenic cells, inhibiting aldosterone release.”

“Approximately half of the basal level is maintained by glucocorticoids whereas physiological fluctuations of aldosterone produce minor changes in sgk1 abundance in adrenal‐intact animals.”

“In vitro aldosterone secretion by adrenal cells from sodium-depleted animals was 252% higher than secretion by cells from controls.”

“It is concluded that the effects of VIP on aldosterone , which are only seen when the architecture of the zona glomerulosa is preserved, may be mediated by the local release of adrenaline.”