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Discover Supplement-Drug Interactions

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Possible Interaction: Aldosterone and Cardiac Glycosides

Research Papers that Mention the Interaction

Conclusion: Aldosterone and salt per se can lead to cell injury that is aggravated in combination or with cardiotonic steroids.
Journal of Vascular Research  •  2012  |  View Paper
aldosterone markedly potentiated the toxic effect of oxygen on transepithelial Na transporL2 Since lipid peroxides had been proposed as … two other membrane-related properties of the toad bladder, the water permeability and the inhibitory effect of the cardiac glycoside ouabain on transepithelial Na transport.… of aldosterone on lipid metabolism.
Annals of the New York Academy of Sciences  •  1981  |  View Paper
Aldosterone and corticosterone production by rat adrenal glomerulosa cells was significantly (P < 0.01) increased by the cardiac glycoside , ouabain octahydrate, at a concentration of 10-5 M. Concentrations greater or less had no effect.
Endocrinology  •  1978  |  View Paper
In isolated, electrically driven rabbit atria, aldosterone (10 -5 M) antagonized the inotropic effect of the cardiac glycosides ouabain and strophanthin when the initial contractile tension was low, viz. ,
The Journal of pharmacology and experimental therapeutics  •  1973  |  View Paper