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Discover Supplement-Drug Interactions
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Last Updated: 3 years ago
drug:
Aldosterone
supplement:
Cardiac Glycosides
Research Papers that Mention the Interaction
“Conclusion: Aldosterone and salt per se can lead to cell injury that is aggravated in combination or with cardiotonic steroids.”
Influence of Aldosterone and Salt or Ouabain in A10 Rat Aorta Smooth Muscle Cells“… aldosterone markedly potentiated the toxic effect of oxygen on transepithelial Na transporL2 Since lipid peroxides had been proposed as … two other membrane-related properties of the toad bladder, the water permeability and the inhibitory effect of the cardiac glycoside ouabain on transepithelial Na transport.… of aldosterone on lipid metabolism.”
“ Aldosterone and corticosterone production by rat adrenal glomerulosa cells was significantly (P < 0.01) increased by the cardiac glycoside , ouabain octahydrate, at a concentration of 10-5 M. Concentrations greater or less had no effect.”
“In isolated, electrically driven rabbit atria, aldosterone (10 -5 M) antagonized the inotropic effect of the cardiac glycosides ouabain and strophanthin when the initial contractile tension was low, viz. ,”
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