Possible Interaction: Aldosterone and Calcium Supplement

“Our data indicate that increases in calcium within the physiological range blunt the diurnal decline in both PRA and aldosterone.”

“In vitro results showed that there was an interaction between calcium ions and aldosterone in macrophages or VSMC.”

“These in vivo and in vitro results suggest that the crosstalk between calcium ions and aldosterone plays an important role in VSMC calcification in uremia via the AIF-1/NF-κB pathway.”

“This study shows that the crosstalk between calcium and aldosterone via the allograft inflammatory factor 1 (AIF-1) pathway contributes to calcium homeostasis and VSMC calcification, which is a novel mechanism of vascular calcification in uremia.”

“In experimental studies it has been demonstrated that aldosterone excess increases renal and fecal loss of calcium [8–10].”

“The Ca ²⁺ uptake in the presence of aldosterone , under conditions where the Ca²⁺ pump is inhibited, showed marked differences from the control.”

“In the present study, we demonstrate that free intracellular calcium is increased rapidly by aldosterone in VSMC and endothelial cells (EC) as determined by single cell imaging of Fura2-fluorescence.”

“In addition to an effect on sodium and potassium, aldosterone can influence the excretion of hydrogen, calcium and magnesium ions and the secretion of renin.”

“Evidence exists that aldosterone excess also affects calcium and mineral homeostasis.”

“Plasma ACTH, cortisol and aldosterone were higher when calcium was administered.”

“It is concluded that ionized calcium influences the plasma levels of aldosterone in uremic patients on regular hemodialysis.”

“Confocal images showed that Ang-(1-7) had no effect on Ca2+ transient parameters, whereas aldosterone increased the magnitude of the Ca2+ transient.”