Allen Institute for Artificial Intelligence logo

Discover Supplement-Drug Interactions

Disclaimer: The information contained herein should NOT be used as a substitute for the advice of an appropriately qualified and licensed physician or other health care provider. The tool is not a substitute for the care provided… (more)
Last Updated: 3 years ago

Possible Interaction: Aldosterone and Antioxidants



Research Papers that Mention the Interaction

In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time-dependent manners, indicating an activation of NLRP3 inflammasome, which was significantly blocked by the mineralocorticoid receptor antagonist eplerenone or the antioxidant N-acetylcysteine.
American journal of physiology. Renal physiology  •  2017  |  View Paper
Similarly, antioxidants and free radical scavengers partially attenuated proapoaptotic effects of aldosterone.
American journal of physiology. Renal physiology  •  2008  |  View Paper
Antioxidants and FRS partially attenuated the proapoaptotic effect of aldosterone.
American journal of physiology. Renal physiology  •  2007  |  View Paper
In the mouse model, aldosterone infusion decreased the amount of cardiac mitochondrial DNA and COX IV protein, and the effects were also attenuated by treatment with an MR antagonist and antioxidant.
Biomedicines  •  2021  |  View Paper