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Discover Supplement-Drug Interactions
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Last Updated: 2 years ago
drug:
Aldosterone
supplement:
Antioxidants
Research Papers that Mention the Interaction
“In vitro, exposure of podocytes to Aldo enhanced NLRP3, caspase-1, and IL-18 expressions in dose- and time-dependent manners, indicating an activation of NLRP3 inflammasome, which was significantly blocked by the mineralocorticoid receptor antagonist eplerenone or the antioxidant N-acetylcysteine.”
NLRP3 inflammasome activation contributes to aldosterone-induced podocyte injury.“Similarly, antioxidants and free radical scavengers partially attenuated proapoaptotic effects of aldosterone.”
“ Antioxidants and FRS partially attenuated the proapoaptotic effect of aldosterone.”
“In the mouse model, aldosterone infusion decreased the amount of cardiac mitochondrial DNA and COX IV protein, and the effects were also attenuated by treatment with an MR antagonist and antioxidant.”
Aldosterone Excess Induced Mitochondria Decrease and Dysfunction via Mineralocorticoid Receptor and Oxidative Stress In Vitro and In Vivo
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